Onsite/Offsite Backups

Hi,

Onsite, we are looking into running two file servers under a DFS namespace with Windows Server 2012, and will set up DFS-R for clustering.

We are looking into options for offsite backups as well. What are some options that you've implemented or recommend? I'm still researching some options, but has anyone set up a server in a colo and done DFS replication to that server? Another person recommended SkyDrive with Office 365, which we are already using (Office 365). I just wanted to get an idea of what best practices and methods IT professionals follow.

Thanks in advance.